Table 2. Tumor expression of markers associated with dedifferentiation and their prognostic impact on disease-specific survival in patients with non-GIST STSs (univariate analyses; log-rank test, n = 249).

Marker expression	Patients(n)	Patients(%)	Median survival(months)	5-Year survival(%)	P
TGF-β1
Low	170	68	62	66	0.016
High	74	30	25	31
Missing	5	2
E-cadherin
Negative	193	77	58	71	0.659
Positive	39	16	48	39
Missing	17	7
Fascin
Low	153	61	80	53	0.006
High	91	37	17	36
Missing	5	2
NF-κB p105
Negative	59	24	NR	60	0.022
Positive	184	74	37	41
Missing	6	2
Par-6α
Low	91	37	62	50	0.283
High	153	61	38	44
Missing	5	2
PKC-ζ
Negative	174	70	57	49	0.042
Positive	66	27	27	37
Missing	9	3
Vimentin
Low	83	34	48	46	0.616
High	157	63	41	45
Missing	9	3

Abbreviations: Non-GIST STS, non-gastro intestinal stromal tumor soft-tissue sarcoma; TGF-β1, transforming growth factor beta 1; NF-κB, nuclear factor-κB; Par-6α, partitioning-defective protein 6α; PKC-ζ, protein kinase C zeta; NR, not reached.