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PrPSc accumulation within the enteric nervous system (ENS). A: IT11 (36 months p.i.), neurons of the myenteric plexus with clear perineuronal and weakly linear staining reaction; B, C: IT06 (12 months p.i.) granular staining reaction of single cells (arrows) in the submucosa directly adjacent to follicles of the PP; Immunohistochemistry, PrP mAb 12F10, Nomarski interference contrast, Bars 20 μm.
