Table 5.

Numeric codes describing the strength of evidence for an association of a gene with a disease.

Code	Kind of evidence
6	Known association of the gene with the disease.
5	Gene is known to interact with an intermediate, and the intermediate has a known association with the disease.
4	Known association of the gene with a function central to disease pathogenesis (for example, insulin secretion for diabetes).
3	Gene is known to interact with an intermediate, and the intermediate has a known association with a function central to disease pathogenesis.
2	Known association of a region containing the gene with the disease.
1	Gene disruption is known to have a general mutagenic effect.
0	No evidence.