Table 2.
Genotype and allele frequencies of IL5−746 C/T, IL6−572C/G and IL13−1112C/T polymorphisms in patients with autoimmune thyroid diseases and control subjects.
| Genetic producibility | Control | All patients with autoimmune thyroid disease | All patients with Graves' disease | All patients with Hashimoto's disease | |||||
|---|---|---|---|---|---|---|---|---|---|
| IL5 | TT | (Low) | 39 (42·9%) | 99 (52·4%) | 52 (54·2%) | 47 (50·5%) | |||
| −746 | CT | 42 (46·2%) | 78 (41·3%) | n.s.† | 36 (37·5%) | n.s.† | 42 (45·2%) | n.s.† | |
| CC | (High) | 10 (10·9%) | 12 (6·3%) | 8 (8·3%) | 4 (4·3%) | ||||
| T allele | (Low) | 120 (65·9%) | 276 (73·0%) | n.s.† | 140 (72·9%) | n.s.† | 136 (73·1%) | n.s.† | |
| C allele | (High) | 62 (34·1%) | 102 (27·0%) | 52 (27·1%) | 50 (26·9%) | ||||
| IL6 | CC | Low | 58 (66·7%) | 114 (53·3%) | 53 (50·0%) | 61 (56·5%) | |||
| −572 | CG | High | 25 (28·7%) | 87 (40·6%) | n.s.† | 47 (44·3%) | n.s.† | 40 (37·0%) | n.s.† |
| GG | High | 4 (4·6%) | 13 (6·1%) | 6 (5·7%) | 7 (6·5%) | ||||
| CC | Low | 58 (66·7%) | 114 (53·3%) | P = 0·0333† | 53 (50·0%) | P = 0·0198† | 61 (56·5%) | n.s.† | |
| CG + GG | High | 29 (33·3%) | 100 (46·7%) | OR = 1·75 | 53 (50·0%) | OR = 2·00 | 47 (43·5%) | ||
| (1·04–2·95) | (1·11–3·49) | ||||||||
| C allele | Low | 141 (81·0%) | 315 (73·6%) | n.s.† | 153 (72·2%) | P = 0·0420† | 162 (75·0%) | n.s.† | |
| G allele | High | 33 (19·0%) | 113 (26·4%) | (P = 0·0536) | 59 (27·8%) | OR = 1·65 | 54 (25·0%) | ||
| (1·02–2·67) | |||||||||
| IL13 | CC | Low | 53 (77·9%) | 108 (74·5%) | 60 (76·9%) | 48 (71·6%) | |||
| −1112 | CT | 14 (20·6%) | 35 (24·1%) | n.s.† | 16 (20·5%) | n.s.† | 19 (28·4%) | n.s.† | |
| TT | High | 1 (1·5%) | 2 (1·4%) | 2 (2·6%) | 0 (0%) | ||||
| C allele | Low | 120 (88·2%) | 251 (86·6%) | n.s.† | 136 (87·2%) | n.s.† | 115 (85·8%) | n.s.† | |
| T allele | High | 16 (11·8%) | 39 (13·4%) | 20 (12·8%) | 19 (14·2%) | ||||
Analysed by χ2 tests; OR, odds ratio (95% confidence intervals); n.s., not significant;
†
versus control.