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Thermal Stability of wild-type interleukin-11 and muteins determined by DSC
TM denotes the transition midpoint temperature, and ΔH indicates the enthalpy of the transition.
| Protein | TM1 | TM2 | TM3 | ΔH1 | ΔH2 | ΔH3 | ΔHTotal |
|---|---|---|---|---|---|---|---|
| °C | kcal mol−1 | ||||||
| Wild type | 27.5 ± 0.05 | 61.5 ± 0.1 | 76.3 ± 0.1 | 68.0 ± 0.3 | 53.6 ± 0.4 | 58.0 ± 0.4 | 179 ± 1 |
| NT-3N | 28.7 ± 0.05 | 63.6 ± 0.1 | 75.5 ± 0.1 | 64.8 ± 0.3 | 53.0 ± 0.4 | 65.5 ± .04 | 183 ± 1 |
| LA/B-O | 68 ± 0.5 | NAa | NA | 245 ± 2 | NA | NA | 245 ± 2 |
a NA, not applicable.
