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CREB1ΔSIM1 mice have an increase in body weight, fat mass, and serum leptin levels on a chow diet. A, body weight in females and males. B, body composition by magnetic resonance imaging (percentage of lean and fat mass) in females and males. C, serum leptin levels in females and males. The data are represented as the means ± S.E. *, <p = 0.05. For n = males/females: WT, n = 10/8; CREB1lox/lox, n = 12/12; SIM1Cre, n = 6 females; CREB1ΔSIM1, n = 11/13. The mice were housed at 22 °C.
