FIGURE 7.

CREB1^ΔSIM1 mice have normal endocrine function. A, in situ hybridization for TRH was performed in CREB1^lox/lox and CREB1^ΔSIM1 mice and subsequently quantified (n = 5). B, total T4 at 22 °C. C and D, total T4 (C) and total T3 (D) after 7 h at 4 °C (n = 8/group). E, corticosterone serum levels in male and female mice at 33 weeks of age on a chow diet. The data are represented as the means ± S.E. For n = males/females: WT, n = 10/8, CREB1^lox/lox, n = 12/12, SIM1^Cre, n = 6 males; CREB1^ΔSIM1, n = 11/13.