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. 2010 Dec 29;286(10):8106–8116. doi: 10.1074/jbc.M110.134692

FIGURE 2.

FIGURE 2.

Nav1 α-subunit levels are decreased in brains from BACE1-null mice. Upper left panel, Western blot showing Nav1.1, Nav1.2, and Nav1.6 α-subunit levels in brain membrane fractions prepared from 1-month-old wild-type (WT), BACE1-heterozygous knock-out (BACE1-HE), and BACE1-null mice (BACE1-KO). Lower left panel, graph showing normalized Nav1.1 protein levels in WT, BACE1-HE, and BACE1-KO normalized against synaptophysin (ANOVA followed by a post hoc Tukey's test; *, p < 0.05; **, p < 0.01; n = 3 for WT, BACE1-HE, and BACE1-KO, respectively). Upper right panel, Western blot showing Nav1.1, Nav1.2 and Nav1.6 α-subunit levels in total brain extract prepared from 1-month-old WT, BACE1-HE, and BACE1-KO; 2% SDS was used to extract total brain homogenates. Lower right panel, a graph showing normalized Nav1.1 protein levels in WT, BACE1-HE, and BACE1-KO normalized against synaptophysin (ANOVA followed by a post hoc Tukey's test; **, p < 0.01; n = 3 for WT, BACE1-HE, and BACE1-KO, respectively).