FIGURE 5.
Global reduction in dADAR activity leads to altered patterns of locomotor activity. A–C, mean activity profile of dAdarWTLoxP (A, n = 30), dAdarhyp (B, n = 30), and dAdar5g1 males (C, n = 16) under 12-h light-dark cycles (white and black bars). Each bar is an average value of time points from three consecutive days. In dAdarWTLoxP, but not dAdarhyp or dAdar5g1 males, anticipation of morning and evening can be observed under both environmental conditions (arrowheads). D, quantification of morning anticipation in the three experimental genotypes. E, mean locomotor activity in male and female dAdar allelic backgrounds. Error bars, S.E. values. **, p < 0.005; ***, p < 0.0005; not significant (ns): p > 0.05 (Mann-Whitney U test).