FIGURE 5.

Etoposide induces cell death in PrxII knockdown cells independently of ATM-p53 pathway. A, effect of a pan-caspase inhibitor, benzyloxycarbonyl (Z)-VAD-fluoromethyl ketone (10 μm), in etoposide (ETO)-induced cell death. B, effect of ATM inhibitor in etoposide-induced cell death. The cells were pretreated with KU55933 (2 μm) for 1 h before etoposide treatment. C, etoposide-induced cell death in parental and p53-deficient HCT116 colon cells. Data in the graph are means ± S.D. of results from three independent death assays as done in Fig. 2 (n = 3; *, p < 0.001, N.S., not significant). N/T, not treated.