TABLE 1.

Dairy and beef cattle SNPs associated with stature within 500 kbp of genes associated with human height

Gene associated with height in humans	Bovine chromosome	Orthologous start and stop position of gene (bp) in cattle	Position of significant SNPs (bp)	Dairy		Beef
				P-value	Effect size (%)a	P-value	Effect size (%)a
HMGA2b,c,d	5	51,740,850–51,890,260	51,770,120	0.69	0.01	2.7 × 10−10	4.03
			52,214,922	0.72	0.00	2.0 × 10−5	1.38
LCORL/NCAPGc,d,e	6	38,153,047–38,199,154	38,256,889	0.05	0.34	1.1 × 10−4	0.97
			38,326,147	0.45	0.07	5× 10−5	1.07
			38,479,643	5.68 × 10−4	0.40	0.76	0.01
			38,500,209	5.68 × 10−4	1.53	0.76	0.01
			38,558,526	2.57 × 10−4	0.50	0.27	0.09
FBP2d	8	85,344,905–85,387,652	84,943,316	8.61 × 10−4	0.06	0.01	0.41
PTCH1c	8	86,551,192–86,621,018	86,576,819	0.60	0.03	9.9 × 10−4	0.70
PAPPAb	8	110,722,545–110,982,014	111,423,182	8.53 × 10−4	1.86	0.66	0.01
GPR126b	9	82,555,167–82,704,883	82,609,868	0.59	0.02	7.7 × 10−4	0.87
PLAG1, CHCHD7, RDHE2b,d,e	14	23,219,718–23,221,723PLAG1	22,720,374	0.19	0.33	1.2 × 10−5	1.47
			22,768,981	0.02	1.14	9.7 × 10−6	1.50
		23,265,198–23,271,074CHCHD7	22,803,367	3.27 × 10−4	2.53	9.9 × 10−6	1.50
			22,838,802	0.11	0.55	4.1 × 10−6	1.62
		23,365,427–23,398,159RDHE2	22,967,675	0.19	0.29	9.0 × 10−5	1.26
			23,519,449	8.63 × 10−5	2.83	5.5 × 10−6	1.66
CABLES1d,e	24	34,619,497–34,683,911	34,436,971	4.35 × 10−4	0.55	0.08	0.24
			34,457,809	5.86 × 10−4	1.47	1.00	0.00
			34,637,479	3.59 × 10−4	0.57	0.22	0.12

P-values that are < 0.001 are shown in bold-face; P-values that are > 0.001 are shown in non-bold-face

^aEffect size (percentage of variation explained) (2pqβ²)/V_A, where p and q are allele frequencies, β is the SNP solution estimate, and V_A is the genetic variance of stature.

^bLettre et al. (2008).

^cWeedon et al. (2008).

^dKim et al. (2010).

^eGudbjartsson et al. (2008).