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. Author manuscript; available in PMC: 2011 Nov 1.
Published in final edited form as: Circ Cardiovasc Imaging. 2010 Sep 20;3(6):727–734. doi: 10.1161/CIRCIMAGING.108.842096

Figure 1.

Figure 1

A) Images from Look-Locker sequence for a patient with tetralogy of Fallot. Regions of interest for the LV myocardium and blood pool are drawn. B) The time vs. signal intensity curves for the blood pool (red) and myocardium (blue), which are fitted to determine the decay constant T1. The inverse, R1, for each is determined before gadolinium administration and at several time points after. C) The relationship of R1 signals between the blood pool and the myocardium before and after gadolinium is linear. The slope of this relationship is the partition coefficient of gadolinium, and determines the fibrosis index. Examples from a patient with cyanosis (Eisenmenger syndrome, blue) and a normal control (pink) are shown. The steeper slope reflects the increase in gadolinium present due to an enlarged extracellular space.