Figure 2.

Sequence comparison of human and mouse RNU7 loci. The U7 genes at human 12p13 (accession number U474924) and mouse chromosome 6F (X54165) along with flanking regions are compared. Note the relatively high degree of upstream similarity, including the functionally conserved control regions called the proximal and distal sequence elements (PSE and DSE, overlined). The human U7 snRNA coding region is also overlined. A single-nucleotide difference between the published RNA sequence (accession number M17910) and the human 12p13 sequence is illustrated. Downstream regions, with the exception of a putative 3′ box terminator sequence (overlined), are not conserved.