Table 1.
Baseline Characteristics of the PREDICT-HD Cohort by Gene Status and Proximity to Diagnosis.
| Variable | Controls (n=196) | Cases | p-value for cases vs. controls | p-value for trend for cases by far, mid and near diagnosis categories | |||
|---|---|---|---|---|---|---|---|
| Far (n=277) | Mid (n=272) | Near (n=184) | All (n=733) | ||||
| Male Gender (%) | 62 (32%) | 90 (32%) | 103(38.%) | 77 (42%) | 270 (37%) | 0.24 | 0.04 |
| Age (sd) | 43.91 (11.37) | 36.85 (8.02) | 42.30 (9.94) | 44.74 (10.24) | 40.85 (9.88) | 0.0008 | <0.0001 |
| CAG repeat length (sd) | 19.98 (3.52) | 41.14 (1.61) | 42.68 (2.18) | 44.34 (3.09) | 42.52 (2.58) | <0.0001 | <0.0001 |
| Parental age of diagnosis (sd) | 44.03 (11.18) | 50.21 (10.21) | 49.40 (10.8) | 47.21 (11.25) | 49.15 (10.75) | <0.0001 | 0.015 |
| UHDRS total motor (sd) | 2.41 (3.06) | 3.47 (3.79) | 4.72 (4.79) | 7.80 (6.74) | 5.02 (5.31) | <0.0001 | <0.0001 |
| UHDRS chorea* (sd) | 0.27 (0.77) | 0.62 (1.26) | 0.92 (1.57) | 1.59 (2.30) | 0.97 (1.73) | <0.0001 | <0.0001 |
| UHDRS dystonia* (sd) | 0.03 (0.19) | 0.06 (0.30) | 0.07 (0.34) | 0.22 (0.78) | 0.10 (0.48) | 0.0005 | 0.001 |
| UHDRS rigidity* (sd) | 0.25 (0.61) | 0.34 (0.70) | 0.32 (0.69) | 0.36 (0.78) | 0.34 (0.72) | 0.08 | 0.79 |
| UHDRS bradykinesia* (sd) | 1.24 (1.79) | 1.33 (1.76) | 2.03 (2.23) | 3.22 (3.02) | 2.07 (2.41) | <0.0001 | <0.0001 |
| UHDRS oculomotor* (sd) | 0.62 (1.28) | 1.12 (1.88) | 1.38 (2.11) | 2.41 (2.65) | 1.54 (2.24) | <0.0001 | <0.0001 |
| Total striatal volume† (sd) | 1.07 (0.10) | 1.02 (0.12) | 0.92 (0.13) | 0.78 (0.14) | 0.92 (0.16) | <0.0001 | <0.0001 |
| Probability of 5 year diagnosis (sd) | N/A | 0.05 (0.03) | 0.20 (0.07) | 0.45 (0.11) | 0.20 (0.17) | <0.0001 | <0.0001 |
*
Domains based on factors by Marder et al. (2000).(19)
†
Volumetric MRI presented as a % of intracranial volume, n=500 Cases (Far=174, Mid=172, Near=132) and n=149 Controls.
sd=standard deviation