Table 4.
Relationship of Individual UHDRS Motor Items and Probability of Diagnosis and Striatal Volumes in Cases.*
Variable | Probability of diagnosis | Striatal Volumes† | |||||
---|---|---|---|---|---|---|---|
Parameter Estimate (× 1000) | SE (× 1000) | p-value | Parameter Estimate (×1000) | SE (×1000) | p-value | ||
Intercept | −86.79 | 24.93 | 0.0005 | 1148.37 | 30.77 | <.0001 | |
Age (years) | 6.07 | 0.56 | <.0001 | −50.00 | 0.68 | <.0001 | |
Gender (f vs m) | −24.84 | 11.14 | 0.03 | 50.76 | 13.31 | 0.0002 | |
Oculomotor | Pursuits | −18.55 | 7.48 | 0.01 | −3.06 | 8.65 | 0.72 |
Saccade Initiation | 19.11 | 5.76 | 0.001 | 1.37 | 7.12 | 0.85 | |
Saccade Velocity | 3.89 | 8.49 | 0.65 | −31.97 | 10.29 | 0.002 | |
Bradykinesia | Dysarthria | 43.16 | 33.66 | 0.20 | 2.46 | 42.18 | 0.95 |
Tongue | −15.16 | 18.21 | 0.41 | −32.57 | 19.19 | 0.09 | |
Finger Taps | 35.06 | 7.23 | <.0001 | −21.66 | 9.07 | 0.02 | |
RAM | 5.2 | 9.18 | 0.57 | −5.08 | 10.59 | 0.63 | |
Luria | 21.69 | 7.19 | 0.003 | −5.85 | 9.01 | 0.52 | |
Gait | 52.76 | 27.77 | 0.06 | −16.16 | 30.85 | 0.60 | |
Tandem | 61.43 | 13.51 | <.0001 | −35.5 | 15.96 | 0.03 | |
Pull Test | −21.32 | 11.64 | 0.07 | 16.41 | 14.16 | 0.25 | |
Body Bradykinesia | −18.81 | 15.53 | 0.23 | 20.42 | 20.02 | 0.31 | |
Rigidity | 5.08 | 7.68 | 0.51 | −9.01 | 8.68 | 0.30 | |
Dystonia | 10.32 | 12.06 | 0.39 | −5.74 | 14.05 | 0.68 | |
Chorea | 9.83 | 3.43 | 0.004 | −9.83 | 3.88 | 0.01 |
Controlling for age and gender
Percent of total of intracranial volume