Table 3.
Meta-analysis results for association of AD with SNPs in CR1, CLU, and PICALM in Caucasians
| SNP | MA | MAF | Unadjusted |
adjusted age sex &
APOE |
Effect direction:
unadjusted/adjusted |
||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| OR | 95% CI | P‡ | OR | 95% CI | P‡ | ADC | ADNI | CAMP | FHS | UM/VU/MSSM | MIRAGE | NIA LOAD | OHSU | TGEN | |||
| CR1 | |||||||||||||||||
|
|
|||||||||||||||||
| rs3818361 | A | 0.26 | 1.14 | 1.07 – 1.22 | 6.1×10−5 | 1.15 | 1.07 – 1.24 | 0.0002 | +/− | +/+ | −/− | +/+ | +/+ | +/+ | +/+ | +/+ | +/+ |
| rs6701713 | A | 0.26 | 1.14 | 1.07 – 1.22 | 8.8×10−5 | 1.15 | 1.07 – 1.24 | 0.0002 | +/− | +/+ | −/− | +/+ | +/+ | +/+ | +/+ | +/+ | +/+ |
| rs1408077 | A | 0.26 | 1.14 | 1.07 – 1.22 | 0.0001 | 1.16 | 1.07 – 1.25 | 0.0002 | +/+ | +/+ | −/− | +/+ | +/+ | +/+ | +/+ | +/+ | +/+ |
| CLU | |||||||||||||||||
|
|
|||||||||||||||||
| rs7012010 | C | 0.39 | 1.10 | 1.03 – 1.17 | 0.0025 | 1.10 | 1.02 – 1.17 | 0.0081 | +/+ | +/+ | ?/? | +/− | +/− | +/+ | +/+ | −/− | +/+ |
| rs3087554 | C | 0.16 | 1.00 | 0.92 – 1.09 | 0.92 | 0.98 | 0.89 – 1.08 | 0.71 | −/− | −/+ | +/+ | −/+ | +/+ | −/− | +/+ | +/+ | ?/? |
| rs11136000 | T | 0.43 | 0.91 | 0.85 – 0.96 | 0.0007 | 0.92 | 0.86 – 0.98 | 0.0096 | −/− | −/− | −/− | −/− | −/+ | −/+ | −/− | −/− | −/+ |
| rs9331888 | G | 0.25 | 0.99 | 0.92 – 1.06 | 0.76 | 0.99 | 0.91 – 1.07 | 0.74 | −/− | −/− | +/+ | −/− | +/+ | −/− | +/+ | +/+ | −/− |
| rs7982 | T | 0.38 | 0.87 | 0.81 – 0.94 | 0.0002 | 0.89 | 0.83 – 0.97 | 0.0046 | −/− | ?/? | −/− | ?/? | −/− | −/− | −/− | ?/? | ?/? |
| PICALM | |||||||||||||||||
|
|
|||||||||||||||||
| rs532470 | G | 0.49 | 1.06 | 1.00 – 1.11 | 0.048 | 1.02 | 0.96 – 1.09 | 0.47 | −/− | −/− | +/+ | +/+ | +/+ | +/+ | +/− | −/− | +/+ |
| rs592297 | C | 0.20 | 0.92 | 0.86 – 0.99 | 0.02 | 0.96 | 0.89 – 1.04 | 0.33 | −/− | +/+ | −/− | −/− | −/+ | −/− | −/+ | +/+ | −/− |
| rs677909 | C | 0.40 | 0.88 | 0.83 – 0.94 | 3.3×10−5 | 0.94 | 0.88 – 1.00 | 0.056 | −/− | +/+ | −/+ | −/− | −/− | −/− | −/− | +/+ | −/− |
| rs636848 | G | 0.24 | 1.02 | 0.96 – 1.08 | 0.6 | 1.00 | 0.93 – 1.07 | 0.98 | −/− | −/− | +/+ | +/+ | −/− | −/− | +/+ | −/− | +/+ |
| rs541458 | C | 0.39 | 0.88 | 0.83 – 0.93 | 2.6×10−5 | 0.94 | 0.88 – 1.00 | 0.048 | −/− | +/+ | −/+ | −/− | −/− | −/− | −/− | −/− | −/− |
| rs561655 | G | 0.29 | 0.89 | 0.84 – 0.94 | 3.4×10−5 | 0.92 | 0.87 – 0.99 | 0.017 | −/− | +/+ | −/− | −/+ | −/− | −/− | −/− | +/− | −/− |
| rs543293 | A | 0.36 | 0.88 | 0.83 – 0.93 | 2.3×10−5 | 0.92 | 0.86 – 0.98 | 0.015 | −/− | −/+ | −/+ | −/− | −/− | −/− | −/− | +/− | −/− |
| rs7941541 | G | 0.28 | 0.89 | 0.83 – 0.95 | 0.0007 | 0.95 | 0.88 – 1.03 | 0.21 | −/− | −/+ | −/+ | −/− | −/− | ?/? | −/− | ?/? | −/− |
| rs3851179 | T | 0.35 | 0.89 | 0.84 – 0.94 | 3.9×10−5 | 0.93 | 0.87 – 0.99 | 0.026 | −/− | −/+ | −/− | +/+ | −/− | −/− | −/− | +/− | −/− |
MA: minor allele; MAF: weighted-average minor allele frequency; OR: odd ratio; 95% CI: 95% confidence interval; P: meta-analysis P value; ?: no data. Other abbreviations are the same as in Table 1.
P-values and odd ratios estimated under an additive model using logistic regression without covariates (unadjusted) and with covariates (adjusted for age, gender, and APOE) in a meta-analysis of nine Caucasian cohorts comprising 5,935 cases and 7,034 cognitively normal controls. Generalized Linear Models were used to estimate case-control data, and Generalized Estimating Equations were used to estimate family-based data.