. Author manuscript; available in PMC: 2011 Dec 1.

Published in final edited form as: Arch Neurol. 2010 Aug 9;67(12):1473–1484. doi: 10.1001/archneurol.2010.201

Table 4.

APOE genotype and allele frequencies, and odds ratios for association of ε4 with Alzheimer’s Disease

Cohort	Subject status	n	% ε4 positive	APOE Genotype frequencies (n/total)						APOE allele frequencies			Association of APOE ε4 with AD^†

				2/2	2/3	2/4	3/3	3/4	4/4	2	3	4	OR	95% CI	P Value
Caucasian Subjects

ADC	Cases	1,582	68.0	0.00	0.03	0.02	0.29	0.49	0.16	0.03	0.55	0.42	5.22	(4.21 – 6.46)	9.3×10⁻⁵²
ADC	Controls	540	28.2	0.01	0.14	0.01	0.57	0.27	0.01	0.08	0.77	0.15	5.22	(4.21 – 6.46)	9.3×10⁻⁵²
ADNI	Cases	286	67.7	0.00	0.02	0.03	0.3	0.47	0.18	0.02	0.55	0.43	4.50	(3.17 – 6.40)	5.1×10⁻¹⁷
ADNI	Controls	195	26.7	0.01	0.11	0.02	0.62	0.23	0.02	0.07	0.79	0.14	4.50	(3.17 – 6.40)	5.1×10⁻¹⁷
CAMP	Cases	123	36.6	0.00	0.1	0.02	0.54	0.27	0.08	0.06	0.72	0.22	1.20	0.70 – 2.07	5.1×10⁻⁰¹
CAMP	Controls	102	31.7	0.00	0.11	0.02	0.58	0.28	0.02	0.06	0.77	0.17	1.20	0.70 – 2.07	5.1×10⁻⁰¹
FHS	Cases	183	35.5	0.02	0.07	0.03	0.56	0.3	0.03	0.07	0.74	0.19	2.10	1.52 – 2.89	5.4×10⁻⁰⁶
FHS	Controls	2,284	20.8	0.00	0.13	0.02	0.66	0.17	0.02	0.08	0.81	0.12	2.10	1.52 – 2.89	5.4×10⁻⁰⁶
UM/VU/MSSM	Cases	1,162	59.4	0.00	0.04	0.02	0.37	0.43	0.15	0.03	0.60	0.37	4.45	3.78 – 5.24	4.7×10⁻⁷¹
UM/VU/MSSM	Controls	1,137	23.2	0.01	0.12	0.02	0.64	0.2	0.02	0.08	0.80	0.12	4.45	3.78 – 5.24	4.7×10⁻⁷¹
MIRAGE	Cases	559	58.1	0.00	0.04	0.03	0.37	0.41	0.14	0.04	0.60	0.36	1.80	1.56 – 2.07	1.2×10⁻¹⁵
MIRAGE	Controls	788	39.5	0.00	0.08	0.02	0.52	0.31	0.07	0.05	0.72	0.23	1.80	1.56 – 2.07	1.2×10⁻¹⁵
NIA LOAD	Cases	985	75.6	0.00	0.02	0.02	0.22	0.55	0.19	0.02	0.51	0.47	9.05	7.34 – 11.17	6.1×10⁻⁹⁴
NIA LOAD	Controls	881	25.5	0.01	0.14	0.03	0.59	0.21	0.01	0.09	0.77	0.14	9.05	7.34 – 11.17	6.1×10⁻⁹⁴
OHSU	Cases	186	40.3	0.00	0.09	0.05	0.51	0.32	0.03	0.07	0.72	0.22	2.30	1.62 – 3.24	2.4×10⁻⁰⁶
OHSU	Controls	421	21.2	0.00	0.17	0.02	0.62	0.18	0.01	0.09	0.80	0.11	2.30	1.62 – 3.24	2.4×10⁻⁰⁶
TGEN	Cases	819	61.5	0.00	0.03	0.04	0.35	0.43	0.15	0.04	0.58	0.38	4.75	3.78 – 5.96	6.9×10⁻⁴¹
TGEN	Controls	517	21.5	0.03	0.12	0.02	0.63	0.19	0.01	0.10	0.79	0.11	4.75	3.78 – 5.96	6.9×10⁻⁴¹
African American Subjects

ADC	Cases	61	70.5	0.00	0.07	0.02	0.23	0.54	0.15	0.04	0.53	0.43	3.92	2.00 – 7.67	6.7×10⁻⁰⁵
ADC	Controls	60	34.4	0.02	0.13	0.1	0.5	0.23	0.02	0.13	0.68	0.18	3.92	2.00 – 7.67	6.7×10⁻⁰⁵
JHU	Cases		nd	nd	nd	Nd	nd	nd	nd	nd	nd	nd	nd	nd	nd
JHU	Controls		nd	nd	nd	Nd	nd	nd	nd	nd	nd	nd
MIRAGE	Cases	180	69.4	0.00	0.03	0.03	0.28	0.49	0.17	0.03	0.54	0.43	2.17	1.65 – 2.85	2.4×10⁻⁰⁸
MIRAGE	Controls	199	48.2	0.00	0.08	0.04	0.44	0.39	0.06	0.06	0.67	0.27	2.17	1.65 – 2.85	2.4×10⁻⁰⁸
Arab Subjects

Wadi Ara	Cases	73	6.8	0.00	0.00	0.00	0.93	0.07	0	0.00	0.97	0.03	2.87	0.54 – 15.26	0.217
Wadi Ara	Controls	80	2.5	0.00	0.00	0.00	0.98	0.03	0	0.00	0.99	0.01	2.87	0.54 – 15.26	0.217
Caribbean Hispanic Subjects

Columbia	Cases	549	40.4	0.01	0.07	0.03	0.52	0.31	0	0.06	0.71	0.23	2.16	1.67 – 2.81	4.9×10⁻⁰⁹
Columbia	Controls	544	23.9	0.01	0.12	0.02	0.64	0.20	0	0.08	0.80	0.13	2.16	1.67 – 2.81	4.9×10⁻⁰⁹

Abbreviations are listed in Tables 1 and 3.