Table 5.
Association of AD with CR1, CLU, and PICALM SNPs stratified by APOE ε4 carrier status and testing statistical interaction with APOE ε4 carrier status in Caucasian cohorts
| Gene/SNP | APOE e4 (−)† | APOE e4 (+)† | SNP*APOE interaction¶ | ||||||
|---|---|---|---|---|---|---|---|---|---|
| OR | 95% CI | P-value | OR | 95% CI | P-value | OR | 95% CI | P-value | |
| CR1 | |||||||||
| rs3818361 | 1.10 | 1.02 – 1.19 | 0.0170 | 1.14 | 1.03 – 1.26 | 0.0120 | 1.01 | 0.99 – 1.03 | 0.2800 |
| rs6701713 | 1.10 | 1.01 – 1.19 | 0.0210 | 1.14 | 1.03 – 1.26 | 0.0110 | 1.01 | 0.99 – 1.04 | 0.2800 |
| rs1408077 | 1.06 | 1.00 – 1.12 | 0.0360 | 1.15 | 1.03 – 1.27 | 0.0099 | 1.06 | 0.97 – 1.16 | 0.1900 |
|
| |||||||||
| CLU | |||||||||
| rs7012010 | 1.10 | 1.00 – 1.20 | 0.0430 | 1.05 | 1.00 – 1.10 | 0.0640 | 1.03 | 0.94 – 1.12 | 0.5100 |
| rs3087554 | 1.01 | 0.90 – 1.14 | 0.8800 | 1.00 | 0.84 – 1.18 | 0.9700 | 1.00 | 0.82 – 1.22 | 1.0000 |
| rs11136000 | 0.91 | 0.84 – 0.98 | 0.0150 | 0.93 | 0.84 – 1.03 | 0.1700 | 0.98 | 0.92 – 1.06 | 0.6500 |
| rs9331888 | 1.03 | 0.93 – 1.14 | 0.5300 | 0.92 | 0.80 – 1.05 | 0.1900 | 0.89 | 0.77 – 1.04 | 0.1400 |
| rs7982 | 0.87 | 0.79 – 0.97 | 0.0092 | 0.92 | 0.81 – 1.05 | 0.2200 | 1.06 | 0.91 – 1.24 | 0.4800 |
|
| |||||||||
| PICALM | |||||||||
| rs532470 | 0.99 | 0.92 – 1.08 | 0.8900 | 1.12 | 1.01 – 1.24 | 0.0300 | 1.11 | 0.98 – 1.25 | 0.1000 |
| rs592297 | 1.04 | 0.97 – 1.11 | 0.3200 | 0.90 | 0.79 – 1.03 | 0.1200 | 0.85 | 0.73 – 1.00 | 0.0480 |
| rs677909 | 0.99 | 0.91 – 1.08 | 0.8000 | 0.86 | 0.77 – 0.96 | 0.0062 | 0.86 | 0.75 – 0.98 | 0.0260 |
| rs636848 | 0.96 | 0.88 – 1.06 | 0.4400 | 1.07 | 0.95 – 1.21 | 0.2700 | 1.07 | 0.92 – 1.23 | 0.3900 |
| rs541458 | 0.99 | 0.91 – 1.08 | 0.8100 | 0.86 | 0.77 – 0.96 | 0.0066 | 0.86 | 0.75 – 0.98 | 0.0270 |
| rs561655 | 0.97 | 0.89 – 1.06 | 0.5000 | 0.83 | 0.75 – 0.93 | 0.0009 | 0.82 | 0.73 – 0.93 | 0.0024 |
| rs543293 | 1.00 | 0.92 – 1.09 | 0.9800 | 0.83 | 0.74 – 0.93 | 0.0011 | 0.81 | 0.71 – 0.93 | 0.0026 |
| rs7941541 | 0.98 | 0.90 – 1.08 | 0.7300 | 0.90 | 0.79 – 1.02 | 0.0990 | 0.89 | 0.79 – 0.99 | 0.0360 |
| rs3851179 | 0.99 | 0.91 – 1.07 | 0.7300 | 0.86 | 0.77 – 0.95 | 0.0034 | 0.84 | 0.74 – 0.95 | 0.0068 |
Abbreviations are as in Table 3.
Meta-analysis P-values and odds ratios estimated under an additive model using logistic regression without covariates among subjects with no APOE ε4 alleles [APOE ε4 (−)] and among individuals with at least one APOE ε4 alleles (APOE ε4 (+)).
Meta-analysis P-values and ORs for the interaction term (SNP*APOE interaction) were evaluated using logistic regression under an additive model including terms for the two main effects (SNP minor allele dosage and the presence of at least one APOE ε4 allele) and their interaction.