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(A) The warfarin drug pathway. (B) The average maintenance dose of warfarin is dependent on VKORC1 (vitamin K 2,3-epoxide reductase complex) and CYP2C9 (cytochrome P450 family 2 subfamily C polypeptide 9) genotypes (data from reference [81]).
INR international normalized ratio, V variant, WT wild-type
