FIG. 2.

TRIM5α polymorphisms present in humans and rhesus macaques. A summary of the studies examining single nucleotide polymorphisms (SNPs) present in human and rhesus macaque TRIM5a genes. The majority of human SNPs are located within the RBCC motif of TRIM5a in regions not thought to govern retroviral specificity (SNPs above the TRIM5a domain structure). Conversely, rhesus macaque SNPs occur predominantly in those regions of the protein that dictate restriction specificity (SNPs below the TRIM5α domain structure).