Figure 4.
Purine release (A) and NO production (B) expressed as percent of baseline from the urothelial side of bladders following hypoosmotic stimulation. Before stimulation the basal purines release was 22.1±4.9, 38.9+/-13.6 and 19.95±4.7 fmol/mg, whereas the baseline NO release was 3.4±0.6, 3.1+/-0.37 and 5.5±1.45 nmol/mg in normal, diabetic and sucrose fed rats respectively (P>0.1 one way ANOVA). The number of experiments was: control n=5, diabetic n=6 and sucrose fed rats n=7. In panel (A) *P<0.05 for normal vs. diabetes group. In panel (B) *P<0.05 for normal vs. diabetes/sucrose groups and **P<0.01 for diabetic vs. sucrose group.