Skip to main content
. 2011 Feb 11;7(2):154–167. doi: 10.7150/ijbs.7.154

Figure 4.

Figure 4

Effects of olmesartan on myocardial protein expressions of GRP78, CHOP, caspase-12 and apoptosis. [4A-C], Representative Western blots showing specific bands for GRP78, CHOP, caspase-12 and GAPDH as an internal control. Equal amounts of protein sample (30 μg) obtained from whole ventricular homogenate were applied in each lane. These bands are representative of three separate experiments. 4A-C, Densitometric data of protein analysis. The mean density value of GRP78, CHOP and caspase-12 was expressed as a ratio relative to that of GAPDH. [4D] Myocardial tissue sections stained for TUNEL-positive apoptotic nuclei (indicated by arrows) in the hearts of myosin-immunized rats (×400). [4D1] Bar graph shows quantitative analysis of TUNEL positive cells. Each bar represents mean ± SEM of 4 to 6 rats. Group N, age-matched untreated rats; group V, EAM rats administered with vehicle; group Olm-10, EAM rats treated with olmesartan (10 mg/kg/day). The values are mean ± SEM. **P<0.01 vs group N; #P<0.05, ##P<0.01 vs group V.