Table 1.
Incidence of osteosarcoma by age group and sex.
| ASR (n) | |||||||
|---|---|---|---|---|---|---|---|
| Ages 0–24 | Ages 25–59 | Ages 60+ | |||||
| Country (years), regional registry | Male | Female | Male | Female | Male | Female | |
| Europe (1958–1997) | 4.0 (990) | 3.1 (712) | 1.7 (484) | 1.2 (339) | 4.5 (465) | 3.1 (490) | |
| East (1968–1997) | 2.8 (114) | 2.1 (82) | 1.5 (59) | 1.3 (56) | 3.3 (36) | 2.4 (42) | |
| Estonia (1968–1997)* | 2.2 (20) | 2.5 (20) | 1.6 (15) | 1.0 (12) | 3.3 (8) | 2.4 (13) | |
| Poland (1978–1997), Cracow City | 2.0 (7) | 3.2(8) | 0.3 (1) | 0.9 (3) | 1.2 (1) | 2.5 (3) | |
| Slovakia (1973–1997)* | 3.0 (87) | 1.9 (54) | 1.6 (43) | 1.5 (41) | 3.5 (27) | 2.4 (26) | |
| North (1958–1997) | 4.8 (104) | 2.9 (60) | 1.9 (49) | 1.6 (40) | 2.6 (23) | 2.3 (31) | |
| Denmark (1978–1997)* | 4.7 (93) | 2.9 (54) | 1.9 (46) | 1.6 (37) | 2.3 (20) | 2.1 (27) | |
| Iceland (1958–1997)* | 4.9 (11) | 2.9 (6) | 1.7 (3) | 1.7 (3) | 6.2 (3) | 5.8 (4) | |
| West (1970–1997) | 4.5 (127) | 3.2 (84) | 2.3 (76) | 1.7 (54) | 2.6 (29) | 3.1 (48) | |
| The Netherlands (1973–1997), Eindhoven | 4.3 (23) | 3.3 (16) | 2.3 (13) | 1.9 (10) | 3.8 (6) | 3.3 (6) | |
| France (1975–1997) | 4.5 (74) | 3.0 (45) | 2.4 (41) | 1.7 (27) | 2.7 (16) | 2.4 (19) | |
| Bas–Rhin (1975–1997) | 4.3 (20) | 3.6 (15) | 1.7 (9) | 2.0 (10) | 2.3 (4) | 2.3 (4) | |
| Calvados (1978–1997) | 2.9 (8) | 3.0 (7) | 2.7 (7) | 2.7 (7) | 2.1 (2) | 3.0 (3) | |
| Doubs (1978–1997) | 6.9 (15) | 2.6 (5) | 2.3 (5) | 1.4 (3) | 6.2 (4) | 1.2 (2) | |
| Isere (1979–1997) | 5.6 (22) | 2.7 (10) | 2.9 (12) | 1.3 (5) | 2.6 (3) | 1.9 (4) | |
| Somme (1983–1997) | 3.1 (6) | 2.8 (5) | 1.8 (3) | 0.6 (1) | 0.9 (1) | 4.2 (3) | |
| Tarn (1983–1997) | 2.8 (3) | 3.4 (3) | 4.2 (5) | 1.1 (1) | 2.9 (2) | 1.8 (3) | |
| Switzerland (1970–1997) | 4.5 (30) | 3.7 (23) | 2.2 (22) | 1.7 (17) | 2.0 (7) | 4.3 (23) | |
| Basel (1983–1997) | 2.1 (2) | 4.5 (4) | 3.1 (5) | 1.7 (3) | 2.2 (1) | 4.8 (5) | |
| Geneva (1970–1997) | 4.9 (8) | 4.4 (7) | 1.6 (4) | 1.4 (4) | 3.4 (3) | 4.8 (7) | |
| St Gall–Appenzell (1983–1997) | 6.2 (9) | 3.6 (5) | 2.8 (5) | 0.5 (1) | 2.0 (1) | 1.2 (1) | |
| Zurich (1983–1996) | 4.5 (11) | 3.0 (7) | 1.9 (8) | 2.2 (9) | 1.2 (2) | 5.1 (10) | |
| South (1973–1997) | 4.3 (102) | 4.3 (91) | 1.9 (49) | 1.1 (29) | 4.1 (43) | 2.4 (33) | |
| Italy (1978–1997) | 5.3 (51) | 4.5 (38) | 1.6 (20) | 0.8 (11) | 3.0 (16) | 2.6 (20) | |
| Florence (1985–1997) | 6.1 (15) | 4.1 (9) | 1.5 (5) | 0.5 (2) | 1.7 (3) | 1.4 (3) | |
| Parma Province (1978–1997) | 4.4 (6) | 4.7 (5) | 2.0 (3) | 1.6 (3) | 4.3 (4) | 1.4 (2) | |
| Ragusa Province (1983–1997) | 3.1 (3) | 4.1 (3) | 1.1 (1) | 1.0 (1) | 3.0 (1) | 6.9 (3) | |
| Torino (1985–1997) | 5.8 (12) | 3.9 (7) | 1.6 (5) | 0.3 (1) | 4.5 (5) | 2.4 (5) | |
| Lombardy, Varese Province (1978–1997) | 5.4 (15) | 5.0 (14) | 1.6 (6) | 0.9 (4) | 2.2 (3) | 3.8 (7) | |
| Spain (1973–1997) | 3.6 (51) | 4.2 (53) | 2.2 (29) | 1.4 (18) | 5.3 (27) | 2.1 (13) | |
| Granada (1985–1997) | 3.2 (8) | 5.8 (13) | 2.8 (6) | 1.9 (4) | 1.4 (1) | 2.2 (2) | |
| Murcia (1983–1996) | 4.2 (15) | 2.0 (7) | 1.6 (5) | 0.3 (1) | 5.1 (5) | 0.7 (1) | |
| Navarra (1973–1997) | 2.4 (7) | 4.5 (12) | 1.5 (4) | 0.8 (2) | 2.1 (2) | 3.1 (3) | |
| Tarragona (1983–1997) | 5.2 (9) | 4.6 (7) | 1.8 (3) | 3.5 (6) | 4.8 (3) | 1.0 (1) | |
| Zaragoza (1978–1997) | 3.4 (12) | 5.0 (14) | 2.9 (11) | 1.3 (5) | 10.7 (16) | 2.9 (6) | |
| UK (1960–1997) | 4.0 (543) | 3.1 (395) | 1.6 (251) | 1.0 (160) | 5.4 (334) | 3.4 (336) | |
| England (1960–1997) | 4.1 (450) | 3.2 (333) | 1.7 (217) | 1.0 (132) | 5.3 (282) | 3.3 (273) | |
| Birmingham & West Midlands (1979–1997) | 3.8 (75) | 3.4 (62) | 1.4 (33) | 0.7 (16) | 3.1 (28) | 2.8 (41) | |
| Merseyside & Cheshire (1975–1997) | 3.9 (44) | 2.8 (30) | 1.4 (17) | 1.0 (11) | 6.5 (34) | 2.6 (22) | |
| North Western Region (1979–1997) | 4.2 (64) | 3.1 (44) | 1.8 (31) | 1.2 (20) | 8.1 (57) | 3.7 (45) | |
| Oxford Region (1985–1997) | 3.6 (24) | 3.1 (18) | 2.1 (17) | 1.1 (8) | 8.6 (23) | 2.1 (8) | |
| South Thames Region (1960–1997) | 4.1 (195) | 3.3 (148) | 1.9 (103) | 1.2 (70) | 5.0 (119) | 3.5 (129) | |
| Yorkshire Region (1983–1997) | 4.6 (48) | 3.2 (31) | 1.3 (16) | 0.6 (7) | 4.5 (21) | 3.8 (28) | |
| Scotland (1975–1997)* | 3.8 (93) | 2.8 (62) | 1.3 (34) | 1.0 (28) | 5.4 (52) | 3.9 (63) | |
| Asia (1963–1997) | 4.1 (890) | 2.5 (512) | 1.5 (294) | 1.1 (207) | 3.1 (114) | 2.4 (105) | |
| Singapore (1968–1997) | 3.9 (71) | 3.9 (63) | 1.5 (23) | 1.2 (18) | 1.7 (4) | 1.7 (5) | |
| Chinese (1968–1997) | 3.7 (56) | 4.1 (56) | 1.7 (22) | 1.3 (17) | 2.0 (4) | 1.9(5) | |
| Malay (1968–1997) | 5.0 (15) | 2.6 (7) | 0.8 (1) | 0.4 (1) | 0.0 (0) | 0.0 (0) | |
| Japan (1963–1997) | 3.2 (229) | 2.1 (137) | 1.2 (104) | 0.7 (58) | 2.3 (43) | 1.8 (44) | |
| Miyagi Prefecture (1978–1997) | 4.1 (37) | 2.2 (18) | 1.4 (15) | 0.7 (8) | 3.6 (11) | 2.2 (9) | |
| Nagasaki City (1973–1997) | 6.1 (13) | 3.4 (8) | 1.6 (4) | 1.0 (3) | 5.4 (4) | 4.9 (5) | |
| Osaka Prefecture (1963–1997) | 2.9 (179) | 2.0 (111) | 1.2 (85) | 0.7 (47) | 2.0 (28) | 1.5 (30) | |
| India (1978–1997) | 3.8 (286) | 1.9 (120) | 1.2 (73) | 1.1 (48) | 3.2 (20) | 2.7 (17) | |
| Chennai (1983–1997) | 4.3 (68) | 2.3 (35) | 1.5 (21) | 1.1 (13) | 3.8 (7) | 1.5 (3) | |
| Mumbai (1978–1997) | 3.7 (218) | 1.8 (85) | 1.1 (52) | 1.1 (35) | 2.9 (13) | 3.2 (14) | |
| Israel (1963–1997), Jews | 5.1 (146) | 3.1 (85) | 2.3 (50) | 2.1 (50) | 4.0 (31) | 2.2 (20) | |
| Kuwait (1983–1997), Kuwaitis | 5.4 (14) | 4.3 (11) | 1.7 (2) | 0.0 (0) | 0.0 (0) | 7.9 (1) | |
| Philippines (1983–1997), Manila | 6.7 (125) | 4.4 (90) | 3.1 (34) | 3.0 (32) | 11.8 (14) | 11.1 (18) | |
| Thailand (1983–1997), Chiang Mai | 3.8 (19) | 1.2 (6) | 1.6 (8) | 0.2 (1) | 2.1 (2) | 0.0 (0) | |
| Latin America (1980–1997) | 5.0 (126) | 4.0 (100) | 2.5 (41) | 1.4 (26) | 2.4 (7) | 1.4 (5) | |
| Colombia (1983–1997), Cali | 7.6 (45) | 3.5 (22) | 2.4 (11) | 2.9 (14) | 0.0 (0) | 1.2 (1) | |
| Costa Rica (1980–1997)* | 3.5 (53) | 3.9 (57) | 1.7 (15) | 0.5 (4) | 1.8 (3) | 0.4 (1) | |
| Ecuador (1985–1997), Quito | 7.0 (28) | 4.9 (21) | 5.3 (15) | 2.1 (8) | 8.2 (4) | 5.3 (3) | |
| USA (1973–1997) | 4.4 (708) | 3.6 (552) | 2.0 (353) | 1.7 (300) | 4.9 (245) | 3.8 (261) | |
| California§ (1973–1997) | 4.3 (238) | 3.7 (188) | 2.2 (136) | 2.2 (141) | 5.2 (87) | 4.0 (97) | |
| Connecticut (1973–1997) | 3.8 (61) | 3.2 (50) | 1.9 (33) | 1.0 (19) | 6.3 (39) | 4.2 (37) | |
| Atlanta, Georgia (1975–1997) | 4.3 (41) | 3.2 (29) | 1.5 (18) | 1.8 (21) | 3.3 (7) | 4.1 (13) | |
| New Orleans, Louisiana (1983–1997) | 4.3 (13) | 3.0 (10) | 3.3 (11) | 1.5 (5) | 7.2 (8) | 5.0 (9) | |
| Detroit, Michigan (1973–1997) | 4.2 (90) | 3.4 (70) | 2.2 (49) | 1.2 (27) | 4.9 (30) | 3.1 (29) | |
| Hawaii (1973–1997) | 5.8 (32) | 4.3 (22) | 1.6 (10) | 1.3 (7) | 3.7 (6) | 2.4 (5) | |
| Iowa (1973–1997) | 4.8 (76) | 3.6 (55) | 2.1 (33) | 1.7 (26) | 5.3 (33) | 4.5 (36) | |
| New Mexico (1973–1997) | 4.3 (35) | 4.7 (38) | 1.6 (12) | 1.1 (8) | 3.2 (7) | 2.5 (7) | |
| Utah (1973–1997) | 4.6 (48) | 4.0 (40) | 1.9 (16) | 1.9 (15) | 2.8 (6) | 4.0 (10) | |
| Seattle, Washington (1974–1997) | 4.9 (74) | 3.6 (50) | 2.0 (35) | 1.7 (31) | 4.3 (22) | 3.0 (18) | |
| Australia (1978–1997) | 3.9 (156) | 2.6 (97) | 1.4 (62) | 1.7 (71) | 7.0 (104) | 3.5 (70) | |
| New South Wales (1983–1997) | 3.8 (68) | 2.1 (36) | 1.8 (36) | 1.6 (32) | 7.5 (50) | 3.2 (30) | |
| South (1978–1997) | 3.0 (18) | 2.7 (15) | 1.0 (6) | 1.2 (7) | 7.8 (18) | 2.6 (8) | |
| Tasmania (1978–1997) | 2.4 (5) | 2.6 (5) | 0.9 (2) | 2.3 (5) | 8.4 (7) | 3.9 (3) | |
| Victoria (1983–1997) | 4.6 (65) | 3.3 (41) | 1.2 (18) | 1.8 (27) | 5.8 (29) | 4.3 (29) | |
| Canada (1983–1997)† | 4.4 (360) | 3.7 (281) | 1.8 (178) | 1.6 (159) | 4.9 (148) | 3.6 (139) | |
| Alberta (1973–1997) | 4.5 (59) | 3.7 (47) | 1.8 (23) | 1.2 (14) | 3.8 (13) | 4.9 (18) | |
| British Columbia (1978–1997) | 5.0 (63) | 4.1 (47) | 1.3 (20) | 1.9 (28) | 3.6 (18) | 4.0 (23) | |
| Manitoba (1958–1997) | 5.6 (53) | 3.6 (33) | 2.1 (18) | 2.3 (19) | 5.0 (16) | 4.4 (16) | |
| New Brunswick (1978–1997) | 3.0 (10) | 1.5 (5) | 1.4 (4) | 0.6 (2) | 4.3 (5) | 3.1 (3) | |
| Newfoundland (1978–1997) | 5.6 (17) | 4.4 (12) | 1.5 (4) | 0.9 (2) | 6.5 (5) | 0.9 (1) | |
| Nova Scotia (1978–1997) | 2.8 (11) | 2.1 (7) | 2.3 (10) | 2.0 (8) | 7.8 (10) | 4.5 (7) | |
| Ontario (1978–1997) | 4.7 (188) | 3.4 (125) | 1.8 (86) | 1.4 (66) | 4.1 (56) | 3.1 (56) | |
| Prince Edward Island (1983–1997) | 4.6 (2) | 7.6 (3) | 2.6 (1) | 2.3 (1) | 0.0 (0) | 5.1 (1) | |
| Saskatchewan (1968–1997) | 4.7 (34) | 4.5 (31) | 1.7 (10) | 1.6 (10) | 2.3 (5) | 2.1 (7) | |
| World total | 4.2 (3230) | 3.1 (2254) | 1.7 (1412) | 1.4 (1102) | 4.6 (1083) | 3.3 (1070) | |
ASR, world age–standardized rate per 1,000,000; n, number of cases; Italics indicate potentially unstable rates based on less than 10 cases;
*
countries with national registries;
§
includes data from registries in Los Angeles and San Francisco;
†
Canada has national and regional registries, both data are shown. The world rates include data from all listed countries and registries.