Table 2.
Microarray results of transcripts showing greater than 5-fold difference in expression between WKY and LEW, in LPS-stimulated macrophages, with <1% false discovery rate (FDR). Data are sorted according to fold change
| Affymetrix transcript identity |
Gene name | Gene Symbol | QTL position |
p-value (LEW vs. WKY LPS) |
Fold- Change (LEW vs. WKY LPS) |
|---|---|---|---|---|---|
| 7113955 | Fc receptor, IgG, low affinity III, related sequence | Fcgr3-rs | Crgn1 | 1.35E-07 | 40.58 |
| 7028278 | Leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3-like | Lilrb3l | 2.44E-09 | 37.47 | |
| 7332712 | Matrix metallopeptidase 7 | Mmp7 | 2.04E-07 | 29.46 | |
| 7216236 | Olfactory receptor 1684 | Olr1684 | 2.92E-07 | 7.22 | |
| 7047485 | Paired-Ig-like receptor B | Pirb | 9.15E-09 | 6.33 | |
| 7367852 | Rattus norvegicus cDNA clone IMAGE:5598800 5-, mRNA sequence | IMAGE:5598800 | 2.01E-05 | 5.97 | |
| 7080742 | Chemokine (C-C motif) ligand 6 | Ccl6 | 1.88E-07 | 5.52 | |
| 7361223 | Similar to putative protein (5S487) | RGD1310819 | 2.34E-07 | 5.31 | |
| 7334400 | Rho GTPase-activating protein | Grit/Rics | 1.23E-07 | −5.39 | |
| 7270146 | Immunoreceptor Ly49si2 | Ly49si2 | 1.60E-06 | −5.40 | |
| 7238766 | Rho family GTPase 3 | Rnd3 | 8.74E-07 | −5.84 | |
| 7132879 | Stathmin-like 4 | Stmn4 | Crgn7 | 1.58E-07 | −7.85 |
| 7270138 | Immunoreceptor Ly49si1 | Ly49si1 | 5.03E-08 | −9.07 | |
| 7025757 | Arginase 1, liver | Arg1 | 7.09E-07 | −14.09 | |
| 7081895 | Insulin-like growth factor 2 mRNA binding protein 1 | Igf2bp1 | 5.65E-10 | −31.52 |
p-value - uncorrected ANOVA p-value; LPS - lipopolysaccharide; Fold-change - positive values show genes down-regulated in WKY, while negative values show genes up-regulated in WKY compared to LEW macrophages