Table 5.
Enrichment of functional annotation terms using DAVID for genes differentially expressed between Lewis and WKY macrophages, with values less than 0.05 after Benjamini multiple testing correction
| BP_FAT GO Term | Genes (n) | p-value | Benjamini |
|---|---|---|---|
| Basal macrophages | |||
| GO:0001775~cell activation | 29 | 6.13E-07 | 1.80E-03 |
| GO:0045321~leukocyte activation | 26 | 1.89E-06 | 2.78E-03 |
| GO:0002250~adaptive immune response | 14 | 2.07E-06 | 2.03E-03 |
| GO:0002460~adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains |
14 | 2.07E-06 | 2.03E-03 |
| GO:0046649~lymphocyte activation | 22 | 4.66E-06 | 3.43E-03 |
| GO:0010033~response to organic substance | 67 | 5.20E-06 | 3.06E-03 |
| GO:0006955~immune response | 38 | 6.04E-06 | 2.96E-03 |
| GO:0043067~regulation of programmed cell death | 52 | 2.13E-05 | 8.93E-03 |
| GO:0010941~regulation of cell death | 52 | 2.40E-05 | 8.78E-03 |
| GO:0002684~positive regulation of immune system process | 25 | 2.63E-05 | 8.56E-03 |
| GO:0002443~leukocyte mediated immunity | 13 | 4.64E-05 | 1.36E-02 |
| GO:0051338~regulation of transferase activity | 28 | 9.21E-05 | 2.44E-02 |
| GO:0001666~response to hypoxia | 21 | 1.03E-04 | 2.50E-02 |
| GO:0043549~regulation of kinase activity | 27 | 1.05E-04 | 2.35E-02 |
| GO:0030155~regulation of cell adhesion | 16 | 1.06E-04 | 2.20E-02 |
| GO:0045859~regulation of protein kinase activity | 26 | 1.19E-04 | 2.31E-02 |
| GO:0042981~regulation of apoptosis | 49 | 1.22E-04 | 2.21E-02 |
| GO:0001816~cytokine production | 10 | 1.39E-04 | 2.37E-02 |
| GO:0048871~multicellular organismal homeostasis | 13 | 1.44E-04 | 2.32E-02 |
| GO:0042127~regulation of cell proliferation | 48 | 1.55E-04 | 2.38E-02 |
| GO:0002449~lymphocyte mediated immunity | 11 | 1.61E-04 | 2.34E-02 |
| GO:0042110~T cell activation | 15 | 1.79E-04 | 2.48E-02 |
| GO:0051174~regulation of phosphorus metabolic process | 34 | 1.85E-04 | 2.44E-02 |
| GO:0019220~regulation of phosphate metabolic process | 34 | 1.85E-04 | 2.44E-02 |
| GO:0050778~positive regulation of immune response | 17 | 2.00E-04 | 2.52E-02 |
| GO:0070482~response to oxygen levels | 21 | 2.37E-04 | 2.86E-02 |
| GO:0009611~response to wounding | 34 | 2.78E-04 | 3.22E-02 |
| GO:0051347~positive regulation of transferase activity | 21 | 3.27E-04 | 3.64E-02 |
| GO:0002252~immune effector process | 15 | 4.03E-04 | 4.30E-02 |
| GO:0042592~homeostatic process | 49 | 4.25E-04 | 4.37E-02 |
| GO:0042325~regulation of phosphorylation | 32 | 4.42E-04 | 4.39E-02 |
| GO:0033674~positive regulation of kinase activity | 20 | 5.00E-04 | 4.79E-02 |
| GO:0048584~positive regulation of response to stimulus | 22 | 5.27E-04 | 4.89E-02 |
| LPS stimulated macrophages | |||
| GO:0001775~cell activation | 30 | 2.01E-06 | 5.87E-03 |
| GO:0046649~lymphocyte activation | 23 | 8.36E-06 | 1.21E-02 |
| GO:0045321~leukocyte activation | 26 | 1.46E-05 | 1.41E-02 |
| GO:0048872~homeostasis of number of cells | 17 | 2.15E-05 | 1.56E-02 |
| GO:0006955~immune response | 38 | 7.69E-05 | 4.40E-02 |
BP_FAT - subset of Biological Process Gene Ontology (GO) terms, generated by the DAVID team. This subset is missing the broadest GO terms for ease of data interpretation; p value - modified Fisher’s exact test (EASE score); Benjamini - Benjamini multiple testing correction value.