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. Author manuscript; available in PMC: 2012 Mar 24.
Published in final edited form as: Brain Res. 2011 Jan 8;1381:134–140. doi: 10.1016/j.brainres.2010.12.088

Table 1.

MAP-2 and synaptophysin immunoreactivity in the hippocampus and cortex of sham-irradiated and irradiated mice treated with or without ACP-105.

Area Occupied by MAP-2 Immunoreactivity (μm2)
DG Ca1 Ca3 SmCtx EntCtx
Sham-Vehicle 7030 ± 1536 5142 ± 1028 7099 ± 1218 5471 ± 800 4726 ± 716
Sham-ACP-105 5670 ± 1464 3297 ± 847 4016 ± 1280 3010 ± 997* 6012 ± 976
Irradiated-Vehicle 8748 ± 928 4703 ± 891 6676 ± 1017 4429 ± 1173 4757 ± 276
Irradiated-ACP-105 6960 ± 1257 4928 ± 1649 5707 ± 1577 4072 ± 1734 4572 ± 1314
Area Occupied by Synaptophysin Immunoreactivity (μm2)
DG Ca1 Ca3 SmCtx EntCtx
Sham-Vehicle 8904 ± 717 3865 ± 1798 4730 ± 1711 3320 ± 1507 3968 ± 895
Sham-ACP-105 8742 ± 728 4239 ± 1397 4964 ± 1122 4568 ± 1578 4722 ± 895
Irradiated-Vehicle 8000 ± 1556 4518 ± 1162 5194 ± 1163 5459 ± 1789 4058 ± 1085
Irradiated-ACP-105 9045 ± 756 4774 ± 1346 5420 ± 1258 3322 ± 1265 4360 ± 608

DG, dentate gyrus of the hippocampus; Ca1 and Ca3 areas of hippocampus; SmCtx, somatosensory cortex; and EntCtx , entorhinal cortex.

*

p < 0.05 versus Sham-Vehicle in the SmCtx. N= 6 brains per group