Table 2.

ESPRIT - First Bacterial Pneumonia Event by Proximal CD4

	IL-2			Control
CD4	Pt yrs	Events	Rate^a)	Pt yrs	Events	Rate^a)	HR^b)	p-val
< 100	64	2	3.13	60	1	1.66	1.93	.59
100 - 199	194	2	1.03	212	3	1.41	0.77	.77
200 - 349	1117	12	1.07	1879	21	1.12	1.01	.97
350 - 499	2540	23	0.91	4011	24	0.60	1.55	.13
500 - 699	3639	22	0.60	4253	23	0.54	1.11	.73
≥ 700	6281	32	0.51	3131	14	0.45	1.10	.77
Total	13836	93	0.67	13547	86	0.63

HR (p) for 100 cells ^c)		0.89 (.001)			0.90 (.05)			Int.^d)
CD4 Coeff (SE)		−0.0012 (0.0004)			−0.0010 (0.0005)			.71
Log10 CD4 Coeff (SE)		−1.537 (0.375)			−1.194 (0.461)			.62

^a)

Rate per 100 person yrs of follow-up in that category. Events are attributed to last CD4 recorded prior to the event. Assumes patient stays in that category until a CD4 is measured in an alternate category, or until the censoring date. Uses interim and visit-associated lab values.

^b)

Hazard ratio (IL-2 vs. control) and p-value from Cox model with treatment group and time-updated CD4 strata.

^c)

HR and p-value for time-updated CD4 (100 cells) from Cox model, run separately by treatment group.

^d)

Interaction p-value is for treatment group by time-updated CD4 in a model containing time-updated CD4, treatment group, and an interaction term.