Table 3a.

Baseline Predictors of First Bacterial Pneumonia Event

			Univariate		Multivariate
Characteristic	Pts	Events*	HR (95% CI)	p-value	HR (95% CI)	p-value
Treatment group
IL-2	2071	93	1.06 (0.79, 1.42)	.68	1.07 (0.80, 1.44)	.65
Control	2040	86	ref		ref
Age (10 yrs)	4111	179	1.36 (1.17, 1.58)	< .001	1.34 (1.14, 1.59)	< .001
Gender
Male	3345	153	ref		ref
Female	766	26	0.72 (0.48, 1.10)	.13	0.97 (0.63, 1.49)	.89
Race
Asian	442	3	0.13 (0.04, 0.40)	< .001	0.17 (0.05, 0.56)	.003
Black	376	15	0.79 (0.47, 1.35)	.39	0.73 (0.42, 1.25)	.25
White/other	3279	161	ref		ref
IV drug use
Yes	433	32	1.94 (1.32, 2.84)	< .001	1.78 (1.09, 2.90)	.02
No/unknown	3678	147	ref		ref
Hep B/C status
Positive to either	730	44	1.44 (1.01, 2.04)	.04	1.09 (0.70, 1.69)	.71
Unknown status	776	23	0.67 (0.43, 1.05)	.08	0.66 (0.42, 1.04)	.08
Negative to both	2605	112	ref		ref
Nadir CD4 (100 cells)	4110	179	0.88 (0.79, 0.97)	.01	0.93 (0.82, 1.05)	.24
BL CD4 (100 cells)	4111	179	0.94 (0.86, 1.03)	.17	0.98 (0.88, 1.09)	.69
HIV-RNA
≥ 500 copies	832	53	1.66 (1.21, 2.29)	.002	2.02 (1.46, 2.81)	< .001
< 500 copies	3269	126	ref		ref
Prior disease
Bact pneumonia as ADI	51	11	6.43 (3.46, 11.93)	< .001	5.38 (2.86, 10.11)	< .001
Other ADI	1012	50	1.38 (0.99, 1.93)	.06	1.16 (0.80, 1.67)	.43
No ADI	3048	118	ref		ref
PJP prophylaxis
yes	253	11	0.98 (0.53, 1.80)	.95	0.68 (0.36, 1.26)	.22
no	3858	168	ref		ref

^*Patients with a first (after randomization) bacterial pneumonia event.