Area under the curve (AUC) for corticosterone (CORT) and adrenocorticotropic hormone (ACTH) levels normalized to pre-stress basal levels in Control, Sham and FPI rats following 30-min restraint stress at post-injury days (PID) 1, 7, and 14. Each histogram represents the mean ± SEM of 6–9 rats per group.
(A) AUC for CORT. Bracket indicates that fluid percussion injury (FPI) rats had significantly larger overall AUC values compared to Controls (p < 0.005) and Sham rats (p < 0.05).
(B) AUC for ACTH, **p <0.005 and ***p<0.0005 for bracketed groups.