Table 2.
Effect of 5 μM KB-R7943 on spontaneous [Ca2+]i transients in rabbit atrioventricular node cells (n = 12).
| Parameters | Control | At 15 s after KB-R7943 exposure | At 40 s after KB-R7943 exposure |
|---|---|---|---|
| Spontaneous [Ca2+]i transient rate (beats/s) | 3.05 ± 0.24 | 1.35 ± 0.24** | 0.58 ± 0.21** |
| [% change, compared with control] | [−53.0 ± 8.0%] | [−79.1 ± 7.4%] | |
| Percentage increase of diastolic Ca2+ baseline compared with control (%) | – | −9.3 ± 3.2$$ | −16.9 ± 2.8$$ |
| [Ca2+]i transient peak (F/F0) (F: the peak fluorescence intensity; F0: the control diastolic Ca2+ baseline) | 1.64 ± 0.08 | 1.44 ± 0.12 | 1.16 ± 0.12** |
| [% change] | [−13.1 ± 3.5%] | [−29.2 ± 4.8%] | |
| [Ca2+]i transient amplitude between baseline and peak (F/F0) (F: the difference of fluorescence intensity between baseline and peak; F0: the control diastolic Ca2+ baseline) | 0.64 ± 0.08 | 0.53 ± 0.11 | 0.33 ± 0.12** |
| [% change] | [−27.6 ± 10.4%] | [−60.6 ± 12.7%] |
When the data were analysed for this table, if spontaneous [Ca2+]i transients had stopped in the presence of KB-R7943, diastolic Ca2+ and [Ca2+]i transient peak had the same values, and spontaneous [Ca2+]i transient rate and [Ca2+]i transient amplitude were taken as 0.
**
P < 0.01 versus control.
$$
P < 0.01 compared with 0.