Table 3.
Histomorphometric Findings at the End of 3 Months in Normal Dogs, Control Dogs and Dogs Treated with Carotid Sinus Baroreflex Activation
| Normal (n=6) |
Control (n=6) |
CSB Activation (n=8) |
|
|---|---|---|---|
| VFRF (%) | 0.0 ± 0.0 | 21.0 ± 2.6* | 15.7 ± 3.8*† |
| VFIF (%) | 3.7 ± 0.2 | 12.3 ± 1.4* | 9.9 ± 0.7*† |
| MCSA (µm2) | 409 ± 26 | 736 ± 57* | 585 ± 22*† |
| CD (cap/fiber) | 1.00 ± 0.0 | 0.95 ± 0.05* | 1.03 ± 0.05† |
| ODD (µm) | 8.9 ± 0.5 | 11.6 ± 0.4* | 10.5 ± 0.3*† |
Cap/cell = capillary density for fiber; CD = capillary density based on capillary to fiber ratio (Cap/fiber); MCSA = myocyte cross-sectional area; ODD = oxygen diffusion distance; VFIF = volume fraction of interstitial fibrosis; VFRF = volume fraction of replacement fibrosis.
*
=p<0.05 vs. Normal,
†
=p<0.05 vs. Control.