Table 1.
Hemodynamic parameters
| HC | LPS | LPS+CO | LPS+ST | LPS+CO+ST | ||
|---|---|---|---|---|---|---|
| HR | BL | 115.2±15.2 | 108.7±6.3 | 106.5±13.7 | 102.2±10 | 98.3±12.3 |
| b/min | 2.5h | 99.7±20.3 | 131.5±17.7 | 112.3±10.3 | 112.7±5.5 | 108.7±16.3 |
| 6h | 103.2±22.2 | 128.7±14 | 116.7±6.9 | 104.0±10.5 | 112.3±15.8 | |
| MAP | BL | 80± 13.9 | 78.2 ±11.2 | 72.8±11.4 | 85±9.4 | 80±12.7 |
| mm Hg | 2.5h | 78±15.3 | 65.7±10.4 | 64±13.5 | 75.3±8.5 | 69.7±8.5 |
| 6h | 91.2±20.6 | 71±13.4 | 71.3±12.8 | 82.3±18.7 | 86.2±19 | |
| MPAP | BL | 15.6±1.2 | 17.6±2.8 | 15.6±1.2 | 14.8±0.4 | 15.1±0.9 |
| mm Hg | 2.5h | 16.6±1.3 | 39±2.19 | 36±2.4 | 36.6±3.5 | 36±4 |
| 6h | 17.3±2.3 | 42.5±3.7 | 30.6±3.7* | 34.5±3.7 | 35.1±3.5 | |
| CVP | BL | 4.7±1.4 | 5.2±1.5 | 4.8±1.3 | 4.2±0.4 | 4.5±1.4 |
| mmHg | 2.5h | 5.7±1.8 | 7.2±1.7 | 7±1.4 | 5.3±1.4 | 6±1.4 |
| 6h | 5.8±2.5 | 7.8±2.3 | 6.7±1.8 | 6.3±1.4 | 6.3±1 | |
| PCWP | BL | 7.7±1.4 | 7.7±1.2 | 6.7±0.8 | 7.3±1.4 | 7.3±1 |
| mmHg | 2.5h | 8.7±1.6 | 10.3±1.5 | 10±1.4 | 9.8±2.6 | 9.5±1.4 |
| 6h | 8.3±2 | 10.7±1.4 | 8.2±1.2 | 9.0±0.9 | 8.8±1 | |
| CO | BL | 4.0±0.8 | 3.9±0.5 | 3.6±0.7 | 3.7±0.4 | 3.7±0.7 |
| l/min | 2.5h | 3.7±1.1 | 3.8±0.8 | 2.8±1.1 | 3±0.8 | 3.1±0.5 |
| 6h | 4.2±1 | 2.5±0.8 | 2.8±1.1 | 2.3±0.5 | 2.9±0.9 | |
| SVR | BL | 1525±284 | 1505±123 | 1536±180 | 1751±98 | 1695±349 |
| dynes/sec/cm-5 | 2.5h | 1602±176 | 1282±343 | 1918±1259 | 1918±462 | 1642±249 |
| 6h | 1624±167 | 2143±783 | 2177±1077 | 2631±733 | 2358±1003 | |
| PVR | BL | 161.2±24.8 | 204.4±17.3 | 208.4±58.5 | 161.7±20.9 | 174.8±38 |
| dynes/sec/cm-5 | 2.5h | 178.9±31 | 669.7±114 | 843±405 | 764±229 | 691±165 |
| 6h | 175.3±30.2 | 1093±398.8 | 734.6±314.3 | 914.9±304 | 788.5±265 |
Effects of treatment on hemodynamic parameters during a 6-h endotoxin infusion. 2.5 hours after the onset of endotoxin infusion treated animals received either 250 ppm inhaled CO continuously, or an iv bolus of 3 mg/kg iv hydrocortisone or both inhaled CO and steroids. Data are expressed as means ±SD at baseline, 2.5 and 6 hours after of LPS infusion (before treatment and 3.5 hours of CO or steroid treatment respectively). Comparisons between LPS group vs treated groups (LPS+CO, LPS+ST, LPS+CO+ST) were made by two-way ANOVA for repeated measurements during treatment period (3-6h) *P<0.05 or **P<0.01. With the exception of parameter changes on HC group all parameters from all groups were <0.05 compared with baseline (ns= HR, MAP). BL= baseline, HR = heart rate, MAP= mean arterial pressure, MPAP= mean pulmonary arterial pressure, CVP=central venous pressure, PCWP=pulmonary capillary wedge pressure, CO=cardiac output, SVR=pulmonary vascular resistance, PVR=systemic vascular resistance.