Table 2.
Blood gases, respiratory parameters and carboxyhemoglobin levels
| HC | LPS | LPS+CO | LPS+ST | LPS+CO+ST | ||
|---|---|---|---|---|---|---|
| pH | BL | 7.46±0.06 | 7.47±0.02 | 7.49±0.03 | 7.48±0.03 | 7.47±0.02 |
| 2.5h | 7.44±0.03 | 7.30±0.06 | 7.35±0.06 | 7.37±0.06 | 7.34±0.04 | |
| 6h | 7.44±0.04 | 7.24±0.07 | 7.29±0.07 | 7.29±0.09 | 7.31±0.05 | |
| PaCO2 | BL | 40.0±5.25 | 39.1±2.2 | 38±1.3 | 38.1±2.6 | 38.8±2.5 |
| mmHg | 2.5h | 40.1±2.83 | 39.9±4.88 | 43.8±5.78 | 44.5±3.99 | 45.8±3.51 |
| 6h | 38.9±3.6 | 47.8±5.4 | 47.7±7.2 | 50.8±11 | 48.8±7.4 | |
| PaO2 | BL | 224.7±37 | 242±22 | 240±21 | 234±10 | 247±17 |
| mm Hg | 2.5h | 229.5±21 | 147±46 | 156±43 | 159±48 | 157±47 |
| 6h | 225.5±19 | 96±24 | 140±65 | 118±38 | 138±60 | |
| BE | BL | 4.2±1.31 | 4.6±1.8 | 5.4±1.2 | 5.0±0.9 | 4.1±1.0 |
| 2.5h | 3.2±0.83 | -3.0±2.45 | -1.3±1.6 | -0.07±1.2 | -0.4±1.62 | |
| 6h | 2.8±1.4 | -6.2±3.3 | -3.4±1.7 | -2.4±2.2 | -1.8±0.9 | |
| COHb | BL | 0.4±0.2 | 0.4±0.2 | 0.3±0.1 | 0.3±0.1 | 0.2±0.1 |
| % | 2.5h | 0.5±0.6 | 0.2±0.2 | 0.47±0.2 | 0.2±0.0 | 0.3±0,1 |
| 6h | 0.3±0.2 | 0.6±0.8 | 7.9±1.8** | 0.3±0.2 | 8.2±2.2** | |
| Crs | BL | 27.3±3.5 | 29.5±4.9 | 26.2±3.4 | 27.8±1.8 | 27.7±3.1 |
| mL/cm | 2.5h | 23.4±1.8 | 17.8±3.2 | 18.2±4.4 | 16.8±1.9 | 17.8±2.9 |
| H2O | 6h | 23.6±1.6 | 15.2±1.8 | 18.4±4.5 | 17±1.9 | 17.6±3.4 |
| Raw | BL | 18.7±2.9 | 18.2±6.1 | 20.1±6 | 19.7±2.9 | 19.4±2.8 |
| CmH2O | 2.5h | 17.7±1.6 | 20.8±5.4 | 24.1±4 | 22.3±3.8 | 24.2±1.5 |
| L/sec | 6h | 19.7±2.1 | 23.4±4.1 | 22.1±4.4 | 21.9±1.9 | 25.5±5.9 |
Effects of treatment of 250 ppm inhaled CO, 3 mg/kg iv steroids or both inhaled CO and steroids on blood gases and respiratory parameters during a 6-h endotoxin infusion. Data are expressed as means ±SD at baseline, 2.5 and 6 hours after the onset of LPS infusion (before treatment and 3.5 hours of CO or steroid treatment respectively) *P<0.05 or **P<0.01 compared LPS group vs treated groups (LPS+CO, LPS+ST, LPS+CO+ST) during treatment period (3-6h). With the exception of changes parameter on HC group, all parameters from all groups were <0.05 compared with baseline (ns= COHb in LPS and LPS+ST groups). BL= baseline, pH=arterial pH, PaO2=arterial partial pressure of oxygen, PaCO2=arterial partial pressure of CO2, BE= base excess COHb=carboxyhemoglobin levels, Crs = respiratory system compliance, Raw=airways resistance.