Table 3.
Blood count, markers of organ function and cortisol levels
| HC | LPS | LPS+CO | LPS+ST | LPS+CO+ST | ||
|---|---|---|---|---|---|---|
| Leucocytes | BL | 14.5±3.4 | 14.6±1.3 | 17.5±4.2 | 18.5±1.9 | 17±2.8 |
| ×109/L | 2.5h | 18.9±5.2 | 1.7±0.3 | 2.8±1 | 2.5±0.4 | 2.8±0.6 |
| 6h | 17.3±4.8 | 2.7±0.7 | 3.8±1.2 | 3.4±1.1 | 4.1±1.1 | |
| Neutrophiles | BL | 7.1±2.4 | 6.7±0.6 | 8.3±3.2 | 9.7±2.7 | 7.7±1.9 |
| ×109/L | 2.5h | 12±4.3 | 0.3±0.1 | 0.4±0.3 | 0.3±0.1 | 0.5±0.2 |
| 6h | 11.9±3.8 | 1.1±0.4 | 1.7±0.7 | 1.5±0.9 | 1.9±1.1 | |
| Creatinine | BL | 82±9.9 | 82.2±7 | 82.7±2 | 82±7 | 79±8.9 |
| μmol/L | 2.5h | 81.5±9.4 | 78.2±6.8 | 79.5±2.6 | 76±6.8 | 78.7±9.4 |
| 6h | 78.3±8.0 | 98.2±19 | 97.8±12 | 99.3±5.2 | 90±11 | |
| Urea | BL | 3.2±0.6 | 2.7±0.5 | 3.3±0.9 | 3.6±0.7 | 3.1±0.6 |
| mmol/l | 2.5h | 2.9±0.6 | 2.4±0.4 | 2.7±0.6 | 2.8±0.8 | 2.6±0.6 |
| 6h | 2.9±0.4 | 3.1±0.6 | 3.0±0.7 | 3.2±0.9 | 2.9±0.8 | |
| Bilirubin | BL | 4.2±0.4 | 4.1±0.4 | 4.5±0.8 | 4.2±0.4 | 4.2±0.4 |
| μmol/L | 2.5h | 4.3±0.5 | 5.0±0.8 | 4.8±0.7 | 4.5±0.5 | 4.5±0.8 |
| 6h | 4.3±0.8 | 12.3±6 | 11.9±3.9 | 12.3±6.0 | 11.2±4.4 | |
| Bil. conj | BL | 1.5±1.1 | 0.5±0.4 | 0.8±0.6 | 1.6±1.3 | 1.3±1.3 |
| μmol/L | 2.5h | 2.4±1.2 | 0.9±0.7 | 1.7±1.3 | 1.7±1.2 | 2.2±1.5 |
| 6h | 2.0±0.8 | 4.7±4 | 6.4±3.8 | 4.2±5.6 | 8.2±4.6 | |
| Troponine I | BL | 0.5±0.3 | 0.5±0.2 | 0.4±0.2 | 0.5±0.3 | 0.5±0.3 |
| ug/L | 2.5h | 0.6±0.3 | 0.6±0.5 | 0.5±0.2 | 0.5±0.1 | 0.3±0.1 |
| 6h | 0.44±0.2 | 1.4±1.4 | 0.6±0.4 | 1.5±2.1 | 0.5±0.1 | |
| Cortisol | BL | 27.3±18 | 68.5±66 | 51.3±53 | 53.7±64 | 41.4±75 |
| nmol/L | 2.5h | 120±34 | 164±21 | 191±79 | 162±32 | 182±52 |
| 6h | 85±3.2 | 137±53 | 128±14 | 334±40** | 322±76.6** |
Effects of treatment of 250 ppm inhaled CO, 3 mg/kg iv steroids or both inhaled CO and steroids on blood count and biochemistry of organ function during a 6-h endotoxin infusion. Data are expressed as means ±SD at baseline, 2.5 and 6 hours after the onset of LPS infusion (before treatment and 3.5 hours of CO or steroid treatment respectively). *P<0.05 or **P<0.01 compared LPS group vs treated groups (LPS+CO, LPS+ST, LPS+CO+ST) during treatment period (3-6h). With the exception of parameter changes on HC group all parameters from all groups were <0.05 compared with baseline (ns=urea, troponine) BL= baseline, Bil Conj = Bilirubin conjugated.