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. Author manuscript; available in PMC: 2011 Mar 5.
Published in final edited form as: Obesity (Silver Spring). 2008 Oct 2;16(12):2593–2600. doi: 10.1038/oby.2008.414

Figure 2.

Figure 2

Diet-induced obesity alters cardiac fatty acid metabolism gene expression. The transcript levels of PPAR-α, PPAR-β/δ, and their target gene mCPT-1 were significantly upregulated in obese (n=3) compared with lean sham animals (n=4). Transcript levels of MCAD tended (P=0.08) to be higher in obese compared with lean sham-operated animals. Repetitve I/R at 3 days was associated with significant downregulation of PPAR-α, mCPT-1, and MCAD transcripts in obese mice (n=8) but not in lean mice (n=9) compared with respective shams. PPAR-β/δ was significantly upregulated in lean repetitive I/R animals but was downregulated in obese repetitive I/R animals compared with respective shams..