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. 2011 Feb 14;8:69. doi: 10.1186/1743-422X-8-69

Table 1.

The HBV seromarkers, genotypes and mutations in patients with HBsAg seroclearance

Patient Genotype Drugs HBsAga HBsAba HBeAga HBeAba HBcAba Mutations in RT Mutations in S
SC-1 UD ETV NEG NEG NEG NEG POS UD UD
SC-2 UD LAM NEG NEG NEG POS POS UD UD
SC-3 UD ETV NEG POS POSb NEG POS UD UD
SC-4 UD LAM NEG POS NEG POS POS UD UD
SC-5 B Peg-IFN NEG NEG NEG POS POS L199V T47A, C48R,
S61L, I68T,
L109P, W196L,
I208T
SC-6 C Peg-IFN, ETV NEG POS POSb NEG POS T54S, H55R
P109Q		 T47A, I68T
Q101K, P111S,
T123K, I126T,
P203R
SC-7 C LAM NEG NEG NEG NEG POS H55R, V56A;
L80I, L180M,
M204I		 T47A, C48R,
S61L, I68T,
L109P, W196L
SC-8 UD Peg-IFN, LAM NEG POS NEG POS POS UD UD
SC-9 UD Peg-IFN NEG POS NEG NEG POS UD UD
SC-10 C Peg-IFN, LAM NEG POS NEG NEG POS S53T, H55S
Y124H, M129L		 A45L, T47V,
W199L, Y200F
SC-11 C LAM NEG NEG NEG NEG POS Y124H, V207I M198L, W199L,
Y200F
SC-12 UD Peg-IFN NEG POS NEG NEG POS UD UD
SC-13 C LAM NEG NEG NEG NEG POS H55R, V56A
L80I, L180M, M204I		 T47A, C48R,
S61L, I68T
L109P, W196L
SC-14 UD LAM NEG POS NEG NEG POS UD UD

Note. SC, patient with HBsAg seroclearance; UD, HBV DNA undetectable by nested PCR; ETV, entecavir; LAM, lamivudine; Peg-IFN, pegylated IFN; NEG, negative; POS, positive; RT, reverse transcriptase; S, S open reading frame; HBsAb, antibody to HBsAg; HBeAb, antibody to HBeAg; HBcAb, antibody to HBcAg.

a HBV serum markers were all determined by chemiluminescent microparticle immunoassay through Abbott ARCHITECT® i2000 system.

b Two of these were seropositive for HBeAg at the time we collected the blood sample. However, both subjects became HBeAg-negative during follow-up.