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Serum total testosterone. Serum total testosterone (TT) values at basal time (T0) and after 3 (T3), 6 (T6) and 12 (T12) months of testosterone replacement therapy. The insert reports the TT levels at basal time (T0) and 1, 2 and 3 months from the beginning of testosterone replacement therapy (T1, T2 and T3, respectively) of the first four patients used to evaluate the time course of tissue androgen permeation. Data are mean ± SEM. * p < 0.05 vs T0.
