Table 5.

Hormonal parameters

Parameter (normal range)	Months
	T0	T3	T6	T12
TT (3.5-8.5 ng/mL)	1.16 ± 0.28	2.72 ± 0.69**	2.18 ± 0.51*	2.99 ± 0.47**
fT (14.7-32.7 pg/mL)	4.33 ± 0.89	7.55 ± 2.34	6.76 ± 1.79	10.57 ± 1.88*
BioT (ng/dL)	0.34 ± 0.1	0.94 ± 0.28*	0.96 ± 0.45*	1.17 ± 0.34*
SHBG (28-94 nmol/L)	77.77 ± 12.12	89.41 ± 20.0	79.76 ± 15.7	54.15 ± 7.22
% fT	0.41 ± 0.04	0.31 ± 0.06	0.31 ± 0.02	0.36 ± 0.04
DHT (250-750 pg/mL)	248.65 ± 32.10	903.7 ± 321.9	582.45 ± 125.9	796.04 ± 137.22*
E2 (10-25 pg/mL)	10.84 ± 1.23	11.65 ± 1.09	12.03 ± 1.71	12.43 ± 2.13
DHT/TT	0.29 ± 0.03	0.28 ± 0.04	0.27 ± 0.02	0.29 ± 0.038
E2/TT	0.01 ± 0.003	0.006 ± 0.001**	0.007 ± 0.0007*	0.005 ± 0.001**
C (50-250 ng/mL)	164.04 ± 30.72	150.2 ± 22.1	131.58 ± 19.74	129.97 ± 15.57

TT: total testosterone, fT: free testosterone; BioT: bioavailable testosterone; SHBG: steroid hormone binding globuline; %fT: percentage of free testosterone; DHT: dehydrotestosterone; E2: estradiol; C: cortisol. Hormone levels determined before (T0) and after 3 (T3), 6 (T6) and 12 (T12) months of testosterone replacement therapy. Values are mean ± SEM (n = 9). Wilcoxon test: * p < 0.05 vs T0; ** p < 0.01 vs T0.