Table 1.
Characteristics of the Study Population
| Characteristic | Total N=211 (%) | With BSI N=82 (%) | With GVHD grade ≥ 2 N=49 (%) |
|---|---|---|---|
| Age | 44 (34, 53)1 | 46 (37, 54)1 | 43 (34, 51)1 |
| Male gender | 115 (55) | 50 (61) | 26 (53) |
| Underlying disease | -- | -- | -- |
| Acute myelogenous leukemia | 63 (30) | 26 (32) | 11 (22) |
| Non-Hodgkins lymphoma2 | 28 (13) | 12 (15) | 5 (10) |
| Chronic myelogenous leukemia | 26 (12) | 9 (11) | 8 (16) |
| Acute lymphocytic leukemia | 25 (12) | 10 (12) | 8 (16) |
| Myelodysplastic syndrome | 19 (9) | 8 (10) | 7 (14) |
| Multiple myeloma | 13 (6) | 5 (6) | 0 (0) |
| Hodgkins lymphoma2 | 12 (6) | 5 (6) | 2 (4) |
| Chronic lymphocytic leukemia | 8 (4) | 2 (2) | 2 (4) |
| Myelofibrosis | 7 (3) | 3 (4) | 3 (6) |
| Aplastic anemia | 5 (2) | 1 (1) | 1 (2) |
| Renal cell carcinoma | 3 (1) | 1 (1) | 1 (2) |
| Paroxysmal nocturnal hemoglobinuria | 2 (1) | 0 (0) | 1 (2) |
| Prior HSCT | 44 (21) | 20 (24) | 5 (10) |
| Reduced intensity HSCT | 89 (42) | 53 (65) | 25 (51) |
| 6/6 HLA match | 196 (93) | 73 (89) | 46 (94) |
| Complete response at HSCT | 55 (26) | 19 (23) | 11 (22) |
| Donor/Recipient CMV serostatus3 | 102 (48) | 44 (54) | 16 (33) |
| D−/R− | 76 (36) | 26 (32) | 23 (47) |
| D+/R+ | 61 (29) | 26 (32) | 9 (18) |
| D+/R− | 33 (16) | 12 (15) | 10 (20) |
| D−/R+ | 41 (19) | 18 (22) | 7 (14) |
Abbreviations: BSI, blood stream infection; GVHD, acute graft versus host disease; HSCT, hematopoietic stem cell transplantation..
Median (interquartile range).
Lymphomas were further classified within the entire group as diffuse large B cell (4), mantle cell (4), follicular cleaved small cell (3), diffuse large cell (2), T cell lymphoblastic (2); and angioimmunoblastic, small B cell, B cell, anaplastic large cell, small noncleaved Burkitts lymphoma, low grade mucosa-associated lymphoid tissue with plasmacytoid features, follicular mixed small and large cell, marginal zone B cell, biphenotypic precursor B cel leukemia/lymphoma, peripheral T cell, immunoblastic, cutaneous T cell, low grade follicular (1 each).
D, donor; R, recipient; “+”, positive; “−”, negative.