Table 3.

Published reports of allopurinol effects on blood pressure in various rat hypertension models.

Study first author (ref. no)	Rat hypertension model	Allopurinol administration	BP measurement	BP effect
Nakazono et al. (13)	SHR	Acute - iv - 17 mg/kg	Tail cuff - one timepoint	lower SBP
Yamamoto et al. (18)	SHR	Chronic - oral - 30 mg/kg/day	Tail cuff - two timepoints	No effect
Laakso et al. (17)	SHR on high-salt diet	Chronic - oral - 10 mg/kg/day	Tail cuff - one timepoint	No effect
Wallwork et al. (15)	Dexamethasone	Chronic - oral - 20–25 mg/day	Direct arterial - one timepoint	Lower SBP and MAP
Ong et al. (20)	Dexamethasone	Chronic - oral - 200 mg/kg/day	Tail cuff - timecourse	No effect
Viel et al. (14)	DOCA-salt	Chronic - oral - 100 mg/kg/day	Tail cuff - one timepoint	Lower SBP
Tian et al. (19)	Dahl-salt sensitive	Chronic - oral - 10 mg/kg/day	Direct arterial - timecourse	No effect
Kasal et al. (21)	L-NAME	Chronic -oral - 40 mg/kg/day	Tail cuff - three timepoints	No effect
Zhang et al. (22)	ACTH	Chronic -oral - 200 mg/kg/day	Tail cuff - timecourse	No effect
Minami et al. (23)	Hypercholesterolemia	Chronic - oral - 10 mg/kg/day	Tail cuff - timecourse	No effect