Table 2.
Piperidine Analogues (For Tables 2-8 only substitutions R1, R2 and the Ring are varied)
 | |||||||
|---|---|---|---|---|---|---|---|
| Compd | R1 | R2 | Ring | n | IC50 (μM) | Kd (μM) | Activation of Viral Infectivity |
| 8 | Cl | F |  |
49 | 65.8 ± 7.1 | 0.3 (5) | 2.1 |
| 9 | Cl | F |  |
1 | >100 | 9.4 | 0.1 |
| 10 | Cl | F |  |
1 | >100 | 4.2 | 0.2 |
| 11 | Cl | F |  |
1 | >100 | 1.9 | 0.0 |
| 12 | Cl | F |  |
1 | >100 | N.D. | 0.0 |
| 13 | Cl | F |  |
1 | >100 | N.D. | 0.0 |
| 14 | Cl | F |  |
1 | >100 | 3.0 | 0.0 |
| 15 | Cl | F |  |
1 | >100 | 4.3 | 0.3 |
| 16 | Cl | F |  |
1 | >100 | 3.4 | 0.2 |
| 17 | Cl | F |  |
1 | >100.0 | N.B. | 0.1 |
| 18 | Cl | F |  |
1 | >100.0 | N.B. | 0.0 |
| 19 | Cl | F |  |
1 | >100.0 | 1 | 0.0 |
| 20 | Cl | F |  |
1 | >100.0 | 1.3 | 0.23 |