Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Analogs based on virtual screening via docking
| Compd | R1 | R2 | Ring | n | IC50 (μM) | Kd (μM) | Activation of viral infectivity |
|---|---|---|---|---|---|---|---|
| 21 | Cl | F |  |
5 | 58 ± 18.6 | 3.3 | 0.5 ± 0.2 |
| 22 | Cl | F |  |
1 | >100.0 | 4.2 | 0.7 ± 0.3 |
| 23 | Cl | F |  |
1 | >100.0 | 2.5 | 0.3 |
| 24 | Cl | F |  |
1 | >100.0 | ND | 0.0 |
| 25 | Cl | F |  |
1 | 27 | 2.3 | 0.0 |
| 26 | Cl | F |  |
1 | >100 | ND | 0.0 |
| 27 | Cl | F |  |
1 | >100.0 | ND | 0.0 |
| 28 | Cl | F |  |
1 | >100.0 | ND | 0.0 |
| 29 | Cl | F |  |
1 | >100 | ND | 0.1 |
