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Analogs based on virtual screening via docking
| Compd | R1 | R2 | Ring | n | IC50 (μM) | Kd (μM) | Activation of viral infectivity |
|---|---|---|---|---|---|---|---|
| 30 | Cl | F |  |
5 | 64.5 ± 21.9 | 4.0 | 0.1 |
| 31 | Cl | F |  |
1 | >100 | ND | 0.0 |
| 32 | Cl | F |  |
1 | >100 | ND | 0.0 |
| 33 | Cl | F |  |
1 | >100 | ND | 0.1 |
| 34 | Cl | F |  |
1 | >100 | ND | 0.0 |
| 35 | Cl | F |  |
1 | >100 | NB | 0.0 |
| 36 | Cl | F |  |
1 | >100 | ND | 0.0 |
| 37 | Cl | F |  |
1 | >100 | ND | 0.0 |
