Table 8.
Mutational sensitivity of NBD analogs
| Compd | R1 | R2 | Ring | n | Wild-type IC50μM | D368A IC50μM | S375A IC50μM |
|---|---|---|---|---|---|---|---|
| 1 | Cl | F |  |
67 | 74.8 ± 5.4 | 29.1 ± 9.9 | 9.6 ± 0.5 |
| 49 | Cl | F |  |
5 | 38.5 ± 10.2 | 86.9 | 9.3 ± 1.4 |
| 50 | Cl | F |  |
3 | 75.5 ± 23.8 | 83.2 | 34.5 ± 5.5 |
Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.