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. 2011 Mar 3;10:4. doi: 10.4103/1477-3163.77274

Figure 1.

Figure 1

Expression of VEGF/VEGFR-2 and some of its key downstream target proteins in mesothelioma. (a) Expression levels of VEGFR-2 and PKC-β1 and PKC-β2 in mesothelioma cell lines as determined by immunoblotting. PKC-β1 and PKC-β2 showed similar levels of expression among all cell lines. However, Met5A (non-malignant mesothelial cells) expressed reduced amounts of VEGFR-2 and PKC-β2 protein. (b) Left panels show the percentage expression of p–AKT, VEGF, VEGFR-2, PKC-β1 and PKC-β2 in epithelioid (EPI), sarcomatoid (SAR) and non-tumor tissue microarray specimens and the representative images on the right panels. Right panels: panels A (strong) and B (weak) show p-AKT nuclear expression in EPI malignant pleural mesothelioma (MPM). Panels C (strong) and D (moderate) show VEGF cytoplasmic expression in EPI and SAR MPM, respectively. Panels E (strong) and F (moderate) show relative expression of VEGFR-2 in EPI MPM. Panels G (moderate) and H (strong) highlight PKC-β1 expression and panels I (weak) and J (moderate) represent PKC-β2 nuclear expression in EPI MPM tissue samples.