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. 2011 Mar 3;10:4. doi: 10.4103/1477-3163.77274

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© 2011 Loganathan

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Effect of inhibition of VEGFR and its downstream target PKC on mesothelioma cell viability. (a) Antiproliferative effect of enzastaurin (1–6 µM) on a panel of malignant mesothelioma cell lines. H2052 shows high resistance to enzastaurin and H2461 is the most sensitive of all the cell lines. (b) Effect of VEGFR inhibitor, KRN633 (1 µg/ml), and enzastaurin (2.5 µM) combination on antiproliferative activity in normal and malignant mesothelioma cell lines. Human Umbilical Vein Endothelial Cells (HUVEC) response to rhVEGF is shown as a positive control. H2461, H513 and H2452 as shown above had the least cell survival among all cell lines and showed statistically significant results.