Figure 4.

Effect of PKC inhibitor on C. elegans morphology. Altered phenotypes of C. elegans in response to enzastaurin are shown. (a) Wild-type N2 adult hermaphrodite showing normal body morphology. (b) Enzastaurin treated N2 showing defective body morphology. (c) Enzastaurin treated worms show large body vacuoles and lack of a normal vulva phenotype. (d) Induction of hyperactive movement in C. elegans by exposure to enzastaurin for few hours. (e) Arrangement of eggs in the uterus of wild-type C. elegans. (f) Altered arrangement of eggs in the uterus of enzastaurin treated wild-type C. elegans. Arrow bar highlights vacuoles of increased size in the body of enzastaurin treated worms.