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. 2010 Nov 15;137(22):3743–3752. doi: 10.1242/dev.051672

Fig. 7.

Fig. 7.

Effects of 4-week attenuation of FGFR2b signaling in postnatal incisors are reversible. (A) Timecourse for postnatal doxycycline treatment followed by different lengths of doxycyline-free chases. (B-O) Whole-mount images of incisors of control (B-H) and DTG (I-O) mice after 4 weeks of doxycyline exposure and 0 (P42; B,I), 28 (P70; C,J), 49 (P91; D,K), 56 (P99; E,L), 66 (P109; F,M), 70 (P113; G,N) and 77 (P120; H,O) days doxycyline-free period before sacrifice. Red and green arrowheads point to abnormal maxillary and mandibular incisors, respectively. (P-R′) Hematoxylin and Eosin staining of proximal incisor sections of a control animal (P,P′) and DTG animals 28 days (P70; Q,Q′) and 77 days (P120; R,R′) post-doxycyline treatment. Boxes in P, Q and R indicate areas magnified in P′, Q′ and R′, respectively. Am, ameloblasts; Od, odontoblasts.