Figure 5.

Binding platforms at DNA breaks. NBS1, MDC1, XRCC1, and XRCC4 act as binding platforms for the recruitment of other DDR factors to DNA breaks promoting DNA damage signaling and/or repair. Dotted lines indicate protein–protein interactions, while horizontal lines at the end of the dotted lines indicate interacting regions. Some interactions involve post-translational modifications. (P) Phosphorylation; (PAR) PARylation. The red and the green semicircles represent BRCT and FHA domains, respectively. (b) Basic region at the end of the first BRCT domain of XRCC1 that interacts with poly(ADP-ribosyl)ated PARPs.