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. 2011 Mar 1;25(5):460–470. doi: 10.1101/gad.2016311

Figure 2.

Figure 2.

Autophagy supports Ras tumorigenesis. (A) Tumor growth of Ras-expressing atg5+/+ and atg5−/− cells. Error bars represent standard errors. (*) P < 0.05; (**) P < 0.01 (t-test). (B) Representative tumor-bearing mice at day 13 (51 and 10) or day 15 (49 and 24) post-injection from A. (C) Histology (H&E) and immunohistochemistry for active caspase-3, p62, or Ub in tumors from A. (D–F) Ras-expressing atg7−/− tumors show reduced growth, elevated apoptosis, and accumulation of p62 and Ub. Error bars represent standard errors. (*) P < 0.05; (**) P < 0.01 (t-test).